Delhi High Court Allows Crucial Amendments to Patent Claims
A recent decision by the Hon’ble Delhi High Court in Cellectis v. Assistant Controller of Patents showcases the delicate balance between judicial scrutiny and patent law, especially in the complex realm of gene-based immunotherapies. The Court’s allowance of amendments to patent claims reflects its willingness to accommodate genuine efforts at clarifying inventive scope— particularly when procedural objections risk overshadowing scientific advancement. At the heart of the matter lies Cellectis’s patent application titled “Method for Engineering Allogenic and Highly Active T-Cells for Immunotherapy.” The invention proposes an ex vivo method for modifying human T-cells using gene editing tools to inactivate both T-cell receptor (TCR) components and immune checkpoint proteins, followed by the introduction of chimeric antigen receptors (CARs) to create universal, highly active, non-alloreactive donorderived T-cells. These modified T-cells promise scalable, off-theshel...